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Frontiers
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The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents
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Gut hormones like ghrelin (↑ hunger) & GLP-1/PYY (↓ hunger) signal to the hypothalamus' arcuate nucleus. Orexigenic (AgRP/NPY) & anorexigenic (POMC/CART) neurons integrate these signals, regulating food intake via Y1/Y5 & Mc4
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Graphical abstract. GLP-1: Glucagon-like peptide-1; LPS:
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Ghrelin, CCK, GLP-1, and PYY(3-36): Secretory Controls and Physiological Roles in Eating and Glycemia in Health, Obesity, and After RYGB
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